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Abstract #2660

Age Related Changes in Diffusion Tensor Indices in the Medial and Lateral Gastrocnemius.

Usha Sinha 1 , Robert Csapo 2 , Vadim Malis 1 , Yanjie Xue 1 , and Shantanu Sinha 2

1 Physics, SDSU, San Diego, CA, United States, 2 Radiology, UCSD, San Diego, CA, United States

Age related changes in muscle alter both fiber architecture (flengths and pennation angles) as well the microstructure (fiber type, diameter, fibrosis). Diffusion tensor imaging allows the mapping of fiber architecture as well as the microstructure. We report age related changes in diffusion tensor indices (eigenvalues and FA) of the medial and lateral gastrocnemius in a cohort of 5 young and 5 old women. All three eigenvalues for both muscles increase with age, significant difference in young and old was seen for nearly all the indices. A decreased fiber diameter and muscle fiber fraction may qualitatively explain the current findings.

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