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Abstract #2635

Evidence for the Detection of Microscopic Diffusion Anisotropy in Human Brain Gray Matter in Vivo

Marco Lawrenz 1,2 and Juergen Finsterbusch 1,2

1 Department of Systems Neuroscience, University Medical Center Hamburg-Eppendorf, Hamburg, Hamburg, Germany, 2 University Medical Centers Hamburg-Kiel-Luebeck, Neuroimage Nord, Hamburg-Kiel-Luebeck, Hamburg-Kiel-Luebeck, Germany

Double-wave-vector diffusion-weighting (DWV) experiments involving two successively applied diffusion weightings are able to detect diffusion anisotropy on a microscopic scale, even if the diffusion macroscopically appears isotropic. This has been demonstrated recently in a human brain white matter region that yields a fractional anisotropy of 0. In this study, human gray matter is targeted in vivo using a DWV sequence with inversion recovery to suppress WM signals and avoid partial volumen effects. While no signal modulation is observed in a fluid phantom, the modulation curve characteristic for diffusion anisotropy is observed although the modulation amplitude is reduced compared to WM.

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