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Abstract #2584

Patient Centered Registration and Analysis of Diffusion MRI for Robust Detection of Spatially Varying Microstructural Changes

Asif K Suri 1,2 , Roman Fleysher 1 , and Michael L Lipton 1,3

1 Albert Einstein College of Medicine, Bronx, NY, United States, 2 Bronx Psychiatric Center, Bronx, NY, United States, 3 Montefiore Medical Center, Bronx, United States

Brain registration of a subject and set of controls to a template is an essential step in determining diffusion abnormalities obtained from MR diffusion imaging. Limitations in the registration process compounded with use of a canonical brain atlas, results in misregistrations that can result in erroneous identification of abnormal diffusion values within subjects. This study attempts to reduce misregistrations using subject based template, which increases the accuracy of registration. This strategy demonstrates a substantial decrease in volume of abnormally low FA attributed to the improved accuracy of registration and can have useful clinical applications.

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