Abstract #2583
INVERSION: A robust method for co-registration of MPRAGE and Diffusion MRI images
Chitresh Bhushan 1 , Justin P. Haldar 1 , Anand A. Joshi 1 , David W. Shattuck 2 , and Richard M. Leahy 1
1
Ming Hsieh Department of Electrical
Engineering, University of Southern California, Los
Angeles, California, United States,
2
Department
of Neurology, University of California, Los Angeles,
California, United States
Accurate registration between MPRAGE and diffusion MRI
images is essential for many multi-modal neuroimaging
studies. We describe a new method, INVERSION (Inverse
contrast Normalization for VERy Simple registratION),
that robustly aligns MPRAGE and b=0 s/mm
2
images
by leveraging known "inverted" contrast relationships
between these two modalities. We transform the contrast
of the b=0s/mm
2
image
to match the contrast of the MPRAGE image, and achieve
consistently accurate registration using the simple sum
of squared differences cost function. Unlike most
multi-modal registration approaches, INVERSION uses a
locally smooth, and frequently convex, cost function
that is relatively easy to numerically optimize.
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