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Abstract #2583

INVERSION: A robust method for co-registration of MPRAGE and Diffusion MRI images

Chitresh Bhushan 1 , Justin P. Haldar 1 , Anand A. Joshi 1 , David W. Shattuck 2 , and Richard M. Leahy 1

1 Ming Hsieh Department of Electrical Engineering, University of Southern California, Los Angeles, California, United States, 2 Department of Neurology, University of California, Los Angeles, California, United States

Accurate registration between MPRAGE and diffusion MRI images is essential for many multi-modal neuroimaging studies. We describe a new method, INVERSION (Inverse contrast Normalization for VERy Simple registratION), that robustly aligns MPRAGE and b=0 s/mm 2 images by leveraging known "inverted" contrast relationships between these two modalities. We transform the contrast of the b=0s/mm 2 image to match the contrast of the MPRAGE image, and achieve consistently accurate registration using the simple sum of squared differences cost function. Unlike most multi-modal registration approaches, INVERSION uses a locally smooth, and frequently convex, cost function that is relatively easy to numerically optimize.

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