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Abstract #2478

Comparison of phase-contrast MRI and arterial tonometry pulse wave velocity quantification in young and old healthy subjects

Erin K Englund 1 , Zachary B Rodgers 1 , Prithvi Shiva Kumar 2 , Michael C Langham 3 , Julio A Chirinos 2 , Raymond R Townsend 2 , and Felix W Wehrli 3

1 Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, United States, 2 Department of Medicine, University of Pennsylvania, Philadelphia, PA, United States, 3 Department of Radiology, University of Pennsylvania, Philadelphia, PA, United States

Pulse wave velocity (PWV) is the speed at which the systolic wave front travels in an artery, and provides a measure of arterial stiffness. While arterial tonometry is a simple method to quantify central artery PWV, it cannot assess PWV in specific segments. MRI measurement of non-gated velocity-encoded projections can provide vessel-specific quantification of PWV in the carotid arteries, aortic arch, descending aorta, and iliofemoral arteries. A full-body segmental MRI PWV protocol was evaluated nine young and nine old healthy subjects compared to arterial tonometry. MRI and tonometry-derived results show that PWV increases with age in each arterial segment.

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