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Abstract #2453

An Analytic Description of Factors Affecting MOLLIs Accuracy Using a Time-Weighted Average Model of T 1 Relaxation

Kelvin Chow 1 and Richard B Thompson 1

1 Department of Biomedical Engineering, University of Alberta, Edmonton, AB, Canada

The MOLLI sequence is commonly used for in-vivo cardiac T 1 mapping but is known to have systematic errors as a function of heart rate, flip angle, T 1 , and T 2 . We hypothesize that the apparent MOLLI relaxation rate (R 1 * ) can be expressed as a time weighted average (TWA) of the driven relaxation rate during bSSFP readouts (R 1 ' ) and the true relaxation rate (R 1 ) between readouts. An algebraic expression for R 1 * is presented and validated through Bloch equation simulations and phantom experiments. The TWA model analytically describes the effects of many of MOLLIs sources of error and provides insight into their interaction.

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