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Abstract #2452

Diffusion Tensor MRI of the remodeled living heart in multiple mechanical states: First experiments in a rat model of chronic myocardial infarction

Maelene Lohezic 1 , Remi Peyronnet 2 , Craig Lygate 1 , Peter Kohl 2,3 , and Jurgen E Schneider 1

1 Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom, 2 National Heart and Lung Institute, Imperial College London, London, United Kingdom, 3 Department of Computer Science, University of Oxford, Oxford, United Kingdom

Myocardial microstructure underpins cardiac function in health and disease, and can be assessed by diffusion tensor MRI (DTI) in a non-destructive manner and throughout the cardiac cycle. Here, we investigate changes in DTI parameters in the live, chronically infarcted, rat heart in multiple mechanical states. In the remote area, the apparent diffusion coefficient increased, while the fractional anisotropy was similar to healthy control, in both slack and contracture states. Also, remodeling translated into an increase in the proportion of right-handed fibers in the remote area while disarray was observed in the infarct zone.

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