Abstract #2434
Cardiac diffusion MRI beyond DTI
Valentina Mazzoli 1 , Martijn Froeling 1,2 , Aart J Nederveen 3 , Klaas Nicolay 1 , and Gustav J Strijkers 1
1
Biomedical NMR, Department of Biomedical
Engineering, Eindhoven University of Technology,
Eindhoven, Netherlands,
2
Department
of Radiology, University Medical Center, Utrecht,
Netherlands,
3
Department
of Radiology, Academic Medical Center, Amsterdam,
Netherlands
Conventional Diffusion Tensor Imaging (DTI) has been
extensively applied to study myocardial fiber
architecture. However, due to the inability in
identifying crossing fibers and low sensitivity on
microstructural characteristics, DTI fails to provide a
detailed picture of the (micro)structure of cardiac
muscle. We therefore proposed the use of DKI and CSD to
the study of the ex-vivo porcine heart. DKI showed a
better sensitivity than normal DTI to regional
microstructural differences across the wall, and CSD was
correctly able to identify crossing myoloaminar
structures. These techniques could be useful for
reaching a deeper knowledge of cardiac structure and
function.
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