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Abstract #2433

Comparison of Cardiac Diffusion Tensor and Generalized Q-Sampling MRI

Eric P. Aliotta 1,2 , Marmar Vaseghi 3 , Kalyanam Shivkumar 3 , and Daniel B. Ennis 1,2

1 Biomedical Physics IDP, University of California, Los Angeles, CA, United States, 2 Department of Radiological Sciences, University of California, Los Angeles, CA, United States, 3 Cardiac Arrhythmia Center & EP Programs, University of California, Los Angeles, CA, United States

Diffusion Tensor MRI (DT-MRI) is currently used to study cardiac microstructure, but several limitations hinder its ability to measure secondary and tertiary directions of diffusion, which are important to our understanding of cardiac myolaminar organization. Generalized Q-sampling MRI (GQ-MRI) overcomes these limitations. We compared primary, secondary, and tertiary directions of diffusion between DT-MRI and GQ-MRI in ex vivo infarcted porcine hearts and showed that the primary directions of diffusion are in excellent agreement (7.1 median difference), but that the secondary and tertiary directions differ by 24.8 and 34.2. This disagreement indicates that DT-MRI may not accurately characterize myolaminar sheet orientation.

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