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Abstract #2431

Accuracy, Precision, and Reproducibility Comparison of T 1 Mapping Sequences

Sbastien Roujol 1 , Sebastian Weingrtner 1,2 , Murilo Foppa 1 , Kelvin Chow 3 , Keigo Kawaji 1 , Kraig V Kissinger 1 , Beth Goddu 1 , Sophie Berg 1 , Peter kellman 4 , Warren J. Manning 1,5 , Richard B. Thompson 3 , and Reza Nezafat 1

1 Department of Medicine, Beth Israel Deaconess Medical Center / Harvard Medical School, Boston, MA, United States, 2 Computer Assisted Clinical Medicine, University Medical Center Mannheim, Heidelberg University, Mannheim, Germany, 3 Department of Biomedical Engineering, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada, 4 National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, United States, 5 Department of Radiology, Beth Israel Deaconess Medical Center / Harvard Medical School, Boston, MA, United States

Quantitative myocardial T 1 mapping provides in-vivo tissue characterization for assessment of cardiomyopathies. The extracellular volume fraction (ECV) can be calculated from pre and post-contrast T 1 maps and shows promise for the detection of diffuse myocardial fibrosis. Several techniques have been recently proposed for myocardial T 1 mapping. However, no comprehensive comparison has been performed across these methods. In this study, we sought to analyze T 1 and ECV measurements in term of accuracy, precision and reproducibility from four T1 mapping techniques: Modified Look-Locker Inversion Recovery (MOLLI), Shortened MOLLI (ShMOLLI), Saturation recovery single-shot acquisition (SASHA), and SAturation Pulse Prepared Heart rate independent Inversion-REcovery sequence (SAPPHIRE).

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