Abstract #2427
In vivo 3D High Resolution Cardiac Diffusion Weighted MRI using Motion Compensated Diffusion-prepared Balanced Steady-State Free Precession Approach: Preliminary Application in Hypertrophic Cardiomyopathy Patients
Christopher Nguyen 1,2 , Zhaoyang Fan 1 , Behzad Sharif 1 , Yi He 3 , Tianjing Zhang 4 , Jing An 4 , Xiaoming Bi 5 , Minjie Lu 6 , Rohan Dharmakumar 1 , Daniel S Berman 1 , Shihua Zhao 6 , and Debiao Li 1,2
1
Biomedical Imaging Research Institute,
Cedars-Sinai Medical Center, Los Angeles, CA, United
States,
2
Bioengineering,
University of California Los Angeles, Los Angeles, CA,
United States,
3
Radiology,
Anzhen Hospital, Beijing, China,
4
MR
Collaborations NE Asia, Siemens Healthcare, Beijing,
China,
5
MR
R&D, Siemens Healthcare, Los Angeles, CA, United States,
6
State
Key Laboratory of Cardiovascular Disease, Fuwai
Hospital, Beijing, China
Myocardial tissue microstructure exhibits fiber disarray
that manifests in a stark increase (50-100% change for
20-70% fibrosis) in trace apparent diffusion coefficient
(trADC). To ensure sensitivity to this change, we
developed a free-breathing bulk motion compensated
diffusion-prepared segmented balanced steady-state free
precession technique capable of 3D high resolution in
vivo cardiac diffusion-weighted MRI. In healthy
volunteers, the proposed technique yielded LV trADC
values consistent with previously reported values.
Preliminary application in HCM patients revealed 40%
increase in trADC in corresponding LGE-identified
fibrotic regions. The proposed diffusion technique may
potentially allow for non-contrast imaging of myocardial
fibrosis in HCM patients.
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