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Abstract #2426

Multi-parametric MRI assessment of myocardial ischemia-reperfusion injury in mice

Adrienne E Campbell-Washburn 1 , Rachel K Dongworth 2 , Thomas A Roberts 3,4 , Anthony N Price 5 , David L Thomas 6 , Roger J Ordidge 7 , Derek M Yellon 2 , Derek J Hausenloy 2 , and Mark F Lythgoe 3

1 Division of Intramural Research, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland, United States, 2 The Hatter Cardiovascular Institute, University College London, London, United Kingdom, 3 Centre for Advanced Biomedical Imaging, University College London, London, United Kingdom, 4 Centre for Mathematics and Physics in the Life Sciences & Experimental Biology, University College London, London, United Kingdom, 5 Division of Imaging Sciences and Biomedical Engineering, St Thomas' Hospital, King's College London, London, United Kingdom, 6 Department of Brain Repair and Rehabilitation, Institute of Neurology, University College London, London, United Kingdom, 7 Centre for Neuroscience, University of Melbourne, Melbourne, Australia

In order to assess myocardial salvage when evaluating new therapeutic strategies for myocardial infarction, we require the measurement of both infarct size and area-at-risk. In this study, a multi-parametric analysis of infarct (late gadolinium enhancement), oedema (T2 mapping) and perfusion (arterial spin labeling, ASL) is presented for ischemia-reperfusion injury in a mouse model. Late enhancement and T2 mapping correspond well to infarct size and area-at-risk (respectively), as expected. Interestingly, multi-slice ASL shows perfusion deficits, which correspond to area-at-risk, despite reperfusion. This platform will be a useful tool for in vivo investigation of AAR pathophysiology following ischemia-reperfusion injury.

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