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Abstract #2384

The Effect of Bolus Dispersion in Semi-Quantitative and Quantitative Contrast-Enhanced Myocardial Perfusion MRI: A Computational Fluid Dynamics Simulation Study on Influencing Factors

Regine Schmidt 1 , Dirk Graafen 1 , Karsten Sommer 1 , Stefan Weber 1 , Hanns-Christian Breit 1 , and Laura Maria Schreiber 1

1 Section of Medical Physics, Department of Radiology, Johannes Gutenberg University Medical Center, Mainz, Germany

The dispersion of a contrast agent bolus during myocardial perfusion MRI was investigated for a coronary bifurcation geometry with stenosis via computational fluid dynamics simulations. Simulations for different outflow conditions through the stenotic branch were performed. Results were analyzed quantitatively and semi-quantitatively. A non-negligible underestimation of myocardial blood flow (MBF) up to -16.1% and normalized upslope (NUS) up to -23.9%, and an overestimation of the myocardial perfusion reserve (index) (MPR(I)) up to 7.5% and 13.1%, respectively, were found. Furthermore, different parameters, e.g. the diffusion coefficient of contrast agent or the non-Newtonian behavior of blood, have been investigated in further simulations.

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