Abstract #2384
The Effect of Bolus Dispersion in Semi-Quantitative and Quantitative Contrast-Enhanced Myocardial Perfusion MRI: A Computational Fluid Dynamics Simulation Study on Influencing Factors
Regine Schmidt 1 , Dirk Graafen 1 , Karsten Sommer 1 , Stefan Weber 1 , Hanns-Christian Breit 1 , and Laura Maria Schreiber 1
1
Section of Medical Physics, Department of
Radiology, Johannes Gutenberg University Medical Center,
Mainz, Germany
The dispersion of a contrast agent bolus during
myocardial perfusion MRI was investigated for a coronary
bifurcation geometry with stenosis via computational
fluid dynamics simulations. Simulations for different
outflow conditions through the stenotic branch were
performed. Results were analyzed quantitatively and
semi-quantitatively. A non-negligible underestimation of
myocardial blood flow (MBF) up to -16.1% and normalized
upslope (NUS) up to -23.9%, and an overestimation of the
myocardial perfusion reserve (index) (MPR(I)) up to 7.5%
and 13.1%, respectively, were found. Furthermore,
different parameters, e.g. the diffusion coefficient of
contrast agent or the non-Newtonian behavior of blood,
have been investigated in further simulations.
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