Abstract #2383
Temporal and Spatial Variation of Baseline Myocardial BOLD Signal Intensity in Cardiac Phase-Resolved BOLD MRI: A Potentially Revealing Insight into Dynamic Changes in Myocardial Oxygenation
Davide Boschetto 1 , Cristian Rusu 1 , Rohan Dharmakumar 2,3 , and Sotirios A. Tsaftaris 1,4
1
IMT Institute of Advanced Studies Lucca,
Lucca, LU, Italy,
2
Biomedical
Imaging Research Institute, Cedars-Sinai Medical Center,
Los Angeles, CA, United States,
3
Medicine,
University of California Los Angeles, Los Angeles, CA,
United States,
4
Electrical
Engineering and Computer Science, Northwestern
University, Evanston, IL, United States
The main aim of this work is to demonstrate rigorously
that myocardial BOLD signal intensity varies across
cardiac phase and myocardial territories. This is
achieved by demonstrating the existence of shifts across
timeseries extracted from CP-BOLD MRI acquisitions in
canines. The application of a circulant dictionary
approach let us represent each original timeseries as a
weighted version of a shifted pattern (i.e., BOLD curve)
learned from the data. By comparing energy distributions
among kernel shifts with Kolmogorov-Smirnov test and by
a fitness function analysis, the presence of shifts is
statistically proven
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