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Abstract #2383

Temporal and Spatial Variation of Baseline Myocardial BOLD Signal Intensity in Cardiac Phase-Resolved BOLD MRI: A Potentially Revealing Insight into Dynamic Changes in Myocardial Oxygenation

Davide Boschetto 1 , Cristian Rusu 1 , Rohan Dharmakumar 2,3 , and Sotirios A. Tsaftaris 1,4

1 IMT Institute of Advanced Studies Lucca, Lucca, LU, Italy, 2 Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, United States, 3 Medicine, University of California Los Angeles, Los Angeles, CA, United States, 4 Electrical Engineering and Computer Science, Northwestern University, Evanston, IL, United States

The main aim of this work is to demonstrate rigorously that myocardial BOLD signal intensity varies across cardiac phase and myocardial territories. This is achieved by demonstrating the existence of shifts across timeseries extracted from CP-BOLD MRI acquisitions in canines. The application of a circulant dictionary approach let us represent each original timeseries as a weighted version of a shifted pattern (i.e., BOLD curve) learned from the data. By comparing energy distributions among kernel shifts with Kolmogorov-Smirnov test and by a fitness function analysis, the presence of shifts is statistically proven

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