Abstract #2377
Probing Myocardial Blood Oxygenation Reserve of Canines with Controlled Hypercapnia Using T2-prepared BOLD MR
Hsin-Jung Yang 1 , Roya Yumul 1 , Richard Tang 1 , Ivan Cokic 1 , Michael Klein 2 , Avinash Kali 1 , Olivia Sobczyk 2 , Behzad Sharif 1 , Jun Tang 1 , Xiaoming Bi 3 , Sotirios Tsaftaris 4 , Diabao Li 1 , Antonio Conte 1 , Joseph Fisher 2 , and Rohan Dharmakumar 1
1
Cedars Sinai Medical Center, Los Angeles,
California, United States,
2
University
of Toronto, Toronto, ON, Canada,
3
Siemens
Medical Solutions, IL, United States,
4
IMT
Institute for Advanced Studies Lucca, Lucca, Italy
Our study evaluated the feasibility of a non-invasive
stress-testing paradigm using a precisely targeted
partial pressure of arterial CO2 (PaCO2) to induce
myocardial hyperemia, and compared this response to
intravenous adenosine using myocardial blood oxygenation
dependent MRI. This is the first proof-of-concept study
to demonstrate that precisely controlled hypercapnia can
induce myocardial hyperemia equivalent to that induced
by adenosine infusion under conditions of health and
coronary narrowing. Coupled with BOLD MRI, this approach
points to a new opportunity for a truly non-invasive
cardiac stress test. Nevertheless, human studies are
needed to examine the practical utility of this
approach.
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