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Abstract #2370

Evaluation of the feasibility to use novel tissue engineered grafts for right ventricular outflow tract reconstruction by magnetic resonance imaging

Dagmar Hartung 1 , Serghei Cebotari 2 , Igor Tudorache 2 , Karolina Theodoridis 2 , Tanja Meyer 2 , Alexandru Mogaldea 2 , Robert Ramm 3 , Katja Hueper 1 , Frank Wacker 1 , Andres Hilfiker 3 , and Axel Haverich 2

1 Radiology, Hannover Medical School, Hannover, Germany, 2 Division of Cardiothoracic, Transplantation, and Vascular Surgery, Hannover Medical School, Hannover, Germany, 3 Leibniz Research Laboratory for Biotechnology and Artificial Organs, Hannover Medical School, Hannover, Germany

In various congenital heart diseases reconstruction of the right ventricular outflow tract (RVOT) is necessary. Pericardium is the currently used material. To improve longterm graft survival new approaches based on regenerative medicine are being developed. We evaluated the feasibility of a novel tissue engineered (TE) graft composed of an allogeneic TE valve combined with an autologous vascularized patch of small intestine (AutoVaM) for RVOT-reconstruction in pigs by MRI. A graft consisting of a TE valve combined with a pericardial patch served as control. Morphological and functional properties of the new AutoVaM-graft were superior to the conventional pericardial graft for RVOT-reconstruction.

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