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Abstract #2283

Multi-Nuclear MR Imaging of Ventilation and Perfusion Distribution Response to Bronchodilator in Asthma

Helen Marshall 1 , Steven Thomas 2 , Juan Parra-Robles 1 , Salman Siddiqui 3 , Richard Kay 4 , Chris E Brightling 3 , and Jim M Wild 1

1 Academic Radiology, University of Sheffield, Sheffield, United Kingdom, 2 Medical Physics, British Columbia Cancer Agency, British Columbia, Canada, 3 Institute for Lung Health, University of Leicester, United Kingdom, 4 Novartis Pharma AG, Basel, Switzerland

Ventilation (V) and perfusion (Q) matching is essential for efficient gas exchange in the lung. Here ventilation and perfusion distributions were imaged at baseline and post-bronchodilator in 5 patients with asthma using 3 He ventilation and 1 H dynamic-contrast-enhanced perfusion MRI. Maps of ventilation, peak perfusion and time-to-peak perfusion were generated and VQ distribution histograms were plotted. Individual patient VQ response to bronchodilator differed but tended towards increased and more homogeneous ventilation and perfusion post-bronchodilator. Multi-nuclear MRI provided high resolution images of regional ventilation and perfusion distributions, and was sensitive to changes in V and Q following bronchodilator administration in asthmatic patients.

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