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Abstract #2282

Comparison of Hyperpolarized Xenon-129 MR and Tc-99m DTPA Aerosol Lung Ventilation Imaging in Patients with COPD and Asthma

Jennifer Benjamin 1 , Talissa A. Altes 1 , Luke Lancaster 1 , Eduard E. de Lange 1 , Frank Goerner 1 , F. William Hersman 2,3 , Iulian C. Ruset 3 , Jaime H. Mata 1 , G. Wilson Miller 1 , Patrice Rehm 1 , Jason Woods 4 , and John P. Mugler, III 1

1 Radiology, University of Virginia, Charlottesville, VA, United States, 2 Physics, University of New Hamshire, Durham, NH, United States, 3 Xemed, Durham, NH, United States, 4 Radiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States

Hyperpolarized Xe-129 MR lung ventilation imaging provides high spatial and temporal resolution images as compared with the clinical standard for lung ventilation imaging, scintigraphy. In this study, Tc-99m DTPA aerosol SPECT scintigraphy was compared with Xe-129 MR lung ventilation imaging in 14 subjects with lung disease (7 asthma and 7 COPD). Ventilation defects were depicted in greater number and conspicuity, and image quality was better with MRI.

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