Abstract #2282
Comparison of Hyperpolarized Xenon-129 MR and Tc-99m DTPA Aerosol Lung Ventilation Imaging in Patients with COPD and Asthma
Jennifer Benjamin 1 , Talissa A. Altes 1 , Luke Lancaster 1 , Eduard E. de Lange 1 , Frank Goerner 1 , F. William Hersman 2,3 , Iulian C. Ruset 3 , Jaime H. Mata 1 , G. Wilson Miller 1 , Patrice Rehm 1 , Jason Woods 4 , and John P. Mugler, III 1
1
Radiology, University of Virginia,
Charlottesville, VA, United States,
2
Physics,
University of New Hamshire, Durham, NH, United States,
3
Xemed,
Durham, NH, United States,
4
Radiology,
Cincinnati Children's Hospital Medical Center,
Cincinnati, OH, United States
Hyperpolarized Xe-129 MR lung ventilation imaging
provides high spatial and temporal resolution images as
compared with the clinical standard for lung ventilation
imaging, scintigraphy. In this study, Tc-99m DTPA
aerosol SPECT scintigraphy was compared with Xe-129 MR
lung ventilation imaging in 14 subjects with lung
disease (7 asthma and 7 COPD). Ventilation defects were
depicted in greater number and conspicuity, and image
quality was better with MRI.
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