Abstract #2259
Interethnic differences in fatty acid composition of deep subcutaneous abdominal adipose tissue
Suresh Anand Sadananthan 1,2 , Navin Michael 1 , Melvin K-S Leow 1,3 , ChinMeng Khoo 4 , Eric Yin Hao Khoo 4 , Yung Seng Lee 1,5 , Peter Gluckman 1 , EShyong Tai 4 , and S. Sendhil Velan 1,6
1
Singapore Institute for Clinical Sciences,
A*STAR, Singapore, Singapore,
2
Department
of Obstetrics & Gynaecology, National University of
Singapore, Singapore, Singapore,
3
Department
of Endocrinology, Tan Tock Seng Hospital, Singapore,
4
Department
of Medicine, National University of Singapore,
Singapore,
5
Department
of Pediatrics, National University of Singapore,
Singapore,
6
Clinical
Imaging Research Centre, A*STAR, Singapore
The study of fat distribution is important to understand
the pathophysiology of obesity-related disorders,
diabetes mellitus and cardiovascular diseases. Several
studies have suggested that the fat distribution is
different across different ethnic groups. In addition to
the analysis of fat distribution, the investigation of
the fatty acid composition is also important because of
their varying metabolic properties and association with
insulin sensitivity. Differences in the fatty acid
composition induced by diet or ethnicity could
potentially make some groups more susceptible to
metabolic disorders. In this study, we investigated the
fatty acid composition in the abdominal deep
subcutaneous adipose tissue of three ethnicities
(Chinese, Malays and Indians) non-invasively using MRS
approaches.
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