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Abstract #2257

Semi-Continuous Regularized Multi-Exponential Fitting Model for Diffusion Weighted Imaging of the Liver

Burkhard Mdler 1,2 and Jrgen Gieseke 2,3

1 Neurosurgery, University of Freiburg, Freiburg, Germany, 2 Philips Healthcare, Hamburg, Germany, 3 Radiology, University of Bonn, Bonn, Germany

Several studies have utilized IVIM for various clinical applications in the abdomen. We tested performance and validity of a novel semi-continuous multi-exponential PFG-diffusion signal analysis for the detection and quantification of vascular perfusion in the liver with a patient friendly free-breathing approach. Classical chi-squared multi-exponential fitting algorithms are susceptible to fail without sufficient SNR. We show that regularized NNLS-techniques together with high number of b-value DWI-acqusition have better performance on the estimates of IVIM parameters and might encourage new attempts of clinical IVIM-based methods in general.

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