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Abstract #2235

Combined Gadoxetic Acid and Gadofosveset Enhanced Liver MRI: A Feasibility and Parameter Optimization Study

Peter Bannas 1,2 , Utaroh Motosugi 1 , Diego Hernando 1 , Mahdi S Rahimi 3 , James H Holmes 4 , and Scott B Reeder 1,5

1 Department of Radiology, University of Wisconsin, Madison, Madison, WI, United States, 2 Department of Radiology, University Medical Center Hamburg-Eppendorf, Hamburg, Hamburg, Germany, 3 Department of Biomedical Engineering, University of Wisconsin, Madison, Madison, WI, United States, 4 Global MR Applications and Workflow, GE Healthcare, Madison, WI, United States, 5 Department of Medical Physics, University of Wisconsin, Madison, Madison, WI, United States

Gadoxetic acid enhanced hepatobiliary phase MRI is useful for detection of hypointense liver metastases. However, vessels and benign cavernous hemangiomas also appear hypointense on gadoxetic acid enhanced MRI and may be difficult to distinguish from one another. We hypothesized that use of an intravascular contrast agent, gadofosveset trisodium, in addition to gadoxetic acid, may address this issue. The purpose of this work was to demonstrate the feasibility of combined use of these two contrast agents and to optimize MR parameters. We concluded that combination of the two contrast agents is feasible and worth testing in a clinical setting.

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