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Abstract #2234

USPIO enhanced MRI in NAFLD; a feasibility and proof of concept study

Loek P. Smits 1 , Bram Coolen 2 , Wouter Nijhof 1 , Jurgen H. Runge 2 , Erik S. Stroes 1 , and Aart J. Nederveen 2

1 Department of Vascular Medicine, AMC, Amsterdam, Netherlands, 2 Department of Radiology, AMC, Amsterdam, Netherlands

Differentiation between simple steatosis and steatohepatitis (NASH) is of clinical and prognostic importance, but no non-invasive diagnostic tests currently available are capable of this. Previous studies showed the promise of iron-oxide particle enhanced MRI as a diagnostic tool to identify patients with NASH. In the present study we present a protocol for ultrasmall particles of iron-oxide (USPIO) enhanced MRI, and demonstrate that patients with NASH have a decreased hepatic uptake of USPIOs. Future studies are needed to show whether USPIO-MRI indeed is capable of differentiation NASH from simple steatosis.

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