Abstract #2230
Effect of weight loss on fatty acid composition of visceral and subcutaneous (deep and superficial) adipose tissues
Suresh Anand Sadananthan 1,2 , Navin Michael 1 , Eric Yin Hao Khoo 3 , Melvin K-S Leow 1,4 , ChinMeng Khoo 3 , Yung Seng Lee 1,5 , Peter Gluckman 1 , EShyong Tai 3 , and S. Sendhil Velan 1,6
1
Singapore Institute for Clinical Sciences,
A*STAR, Singapore, Singapore,
2
Department
of Obstetrics & Gynaecology, National University of
Singapore, Singapore, Singapore,
3
Department
of Medicine, National University of Singapore,
Singapore,
4
Department
of Endocrinology, Tan Tock Seng Hospital, Singapore,
5
Department
of Pediatrics, National University of Singapore,
Singapore,
6
Clinical
Imaging Research Centre, A*STAR, Singapore
In addition to study of fat distribution in abdominal
adipose tissues (visceral, deep and superficial
subcutaneous), there has been an increasing interest in
the investigation of fatty acid composition in these
depots because of their association with insulin
sensitivity. Studies have shown that the fatty acid
makeup of the different fat compartments vary between
each other. Weight loss intervention is known to alter
this composition in adipose tissues, with studies
showing decreased levels of monounsaturated fatty acids
after intervention. In this study, we investigated the
potential for non-invasively monitoring the changes in
the fatty acid composition of adipose tissue
triglycerides due to weight loss intervention using MRS.
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