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Abstract #2230

Effect of weight loss on fatty acid composition of visceral and subcutaneous (deep and superficial) adipose tissues

Suresh Anand Sadananthan 1,2 , Navin Michael 1 , Eric Yin Hao Khoo 3 , Melvin K-S Leow 1,4 , ChinMeng Khoo 3 , Yung Seng Lee 1,5 , Peter Gluckman 1 , EShyong Tai 3 , and S. Sendhil Velan 1,6

1 Singapore Institute for Clinical Sciences, A*STAR, Singapore, Singapore, 2 Department of Obstetrics & Gynaecology, National University of Singapore, Singapore, Singapore, 3 Department of Medicine, National University of Singapore, Singapore, 4 Department of Endocrinology, Tan Tock Seng Hospital, Singapore, 5 Department of Pediatrics, National University of Singapore, Singapore, 6 Clinical Imaging Research Centre, A*STAR, Singapore

In addition to study of fat distribution in abdominal adipose tissues (visceral, deep and superficial subcutaneous), there has been an increasing interest in the investigation of fatty acid composition in these depots because of their association with insulin sensitivity. Studies have shown that the fatty acid makeup of the different fat compartments vary between each other. Weight loss intervention is known to alter this composition in adipose tissues, with studies showing decreased levels of monounsaturated fatty acids after intervention. In this study, we investigated the potential for non-invasively monitoring the changes in the fatty acid composition of adipose tissue triglycerides due to weight loss intervention using MRS.

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