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Abstract #2229

Assessment of Intrahepatic Lipid Composition during Calorie Restriction and Exercise Intervention in Diet Induced Obese Rats by MRS

Venkatesh Gopalan 1 , Jadegoud Yaligar 1 , Swee Shean Lee 1 , Navin Michael 2 , and S Sendhil Velan 1,2

1 Laboratory of Molecular Imaging, Singapore Bioimaging Consortium, Singapore, Singapore, 2 Singapore Institute for Clinical Sciences, Singapore, Singapore

Hepatic fat plays a major role in metabolic diseases including obesity, diabetes, and non-alcoholic fatty liver disease (NAFLD). In vivo magnetic resonance spectroscopy (MRS) permits non-invasive longitudinal assessment of fat fraction, saturated and unsaturated lipids. Interventions including exercise and calorie restriction play a major role in anti-obesity and also for recovery from NAFLD. In the current study we have estimated the changes in intrahepatic lipid content including, fat fraction, total unsaturated lipids (TUL), fraction of unsaturated lipid (fUL) and unsaturation index (UI) in five groups of high fat diet (HFD) fed obese rat model with exercise and calorie restriction interventions. Our preliminary results suggest significant reduction and modulation of intrahepatic lipids with exercise and calorie restriction.

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