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Abstract #2207

Assessment of Renal Inflammatory Cell Infiltration in a Murine ANCA-Induced Glomerulonephritis Model by 19F-MRI

Andreas Pohlmann 1 , Adrian Schreiber 2 , Min-Chi Ku 3 , Helmar Waiczies 4 , Stefanie Kox 1 , Ralph Kettritz 2 , Sonia Waiczies 1 , and Thoralf Niendorf 1,5

1 Berlin Ultrahigh Field Facility, Max Delbrueck Center for Moleculare Medicine, Berlin, Germany, 2 Clinic for Nephrology and Intensive Care Medicine, Campus Virchow, Charit Medical Faculty, Berlin, Germany, 3 Berlin Ultrahigh Field Facility, Max Delbrueck Center for Molecular Medicine, Berlin, Germany, 4 MRI.TOOLS GmbH, Berlin, Germany, 5 Experimental and Clinical Research Center, Charite Medical Faculty and the Max Delbrueck Center for Molecular Medicine, Berlin, Germany

Anti-neutrophil cytoplasmic antibodies (ANCA) are responsible for the development of small vessel vasculitis. Currently, diagnosis of the initial inflammation and its recurrences relies on kidney biopsies, hence, the clinical need for non-invasive methods. We have employed multi-modal fluorescently (DiI) and 19F labeled nanoparticles to identify specific inflammatory cell populations tested the hypothesis that 19F MRI after in-vivo 19F-labeling of monocytes and neutrophils allows non-invasive detection of ANCA-induced renal inflammation. Our data suggest that 19F-MRI may represent a novel non-invasive method for the assessment of renal inflammation in mouse models with the potential of translation into a clinical tool for the diagnosis of glomerulonephritis in patients.

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