Abstract #2206
Parametric Mapping of Renal T2* Demonstrates Beneficial Effect of Epoxyeicosatrienoic Acid for Preventing Acute Kidney Injury
Andreas Pohlmann 1 , Jan Hentschel 1 , Uwe Hoff 2 , Gordana Bubalo 2 , Mandy Fechner 2 , Maximilian Blum 3 , Ye Zhu 2 , Karen Arakelyan 1,4 , Erdmann Seeliger 4 , Bert Flemming 4 , Dennis Gurgen 2 , Wolfgang Schneider 3 , Michael Rothe 5 , Vijaya L Manthati 6 , John R Falck 6 , Wolf-Hagen Schunck 3 , Duska Dragun 2 , and Thoralf Niendorf 1
1
Berlin Ultrahigh Field Facility, Max
Delbrueck Center for Moleculare Medicine, Berlin,
Germany,
2
Nephrology
and Intensive Care Medicine, Campus Virchow-Klinikum and
Center for Cardiovascular Research,
Charite-Universitaetsmedizin Berlin, Berlin, Germany,
3
Experimental
and Clinical Research Center, Charite Medical Faculty
and the Max Delbrueck Center for Molecular Medicine,
Berlin, Germany,
4
Institute
of Physiology and Center for Cardiovascular Research,
Charit Medical Faculty, Berlin, Germany,
5
Lipidomix
GmbH, Berlin, Germany,
6
Biochemistry
Department, UT Southwestern, Dallas, TX, United States
Current therapeutic options for treating acute kidney
injury (AKI) are disappointing and hence the need for
establishing druggable targets. Imbalances in cytochrome
P450 (CYP)-dependent eicosanoid formation may play a
central role in AKI. Imbalance between renal oxygen
demand and supply is considered to be the initiating
step in the pathophysiologic cascade of events. In this
study we investigated whether administration of an
epoxyeicosatrienoic acid (EET) agonist improves renal
reoxygenation during the initial 2 h reperfusion phase.
Parametric mapping of renal T2* demonstrated improved
renal re-oxygenation after EET treatment. EET agonists
may provide novel therapeutic options for prevention of
ischemic AKI.
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