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Abstract #2188

Arterial Spin Labeling and Diffusion Tensor Imaging of Early Kidney Changes in Pediatric Sickle Cell Disease Patients

Shannon Donnola 1 , Lan Lu 1,2 , Jane Little 3 , Katherine Dell 4 , Connie Piccone 5 , and Chris Flask 1,6

1 Radiology, Case Western Reserve University, Cleveland, Ohio, United States, 2 Urology, Case Western Reserve University, Cleveland, Ohio, United States, 3 Hematology and Oncology, University Hosptials-Case Medical Center, Cleveland, Ohio, United States, 4 Pediatrics, Cleveland Clinic Lerner College of Medicine, Cleveland, Ohio, United States, 5 Pediatrics, University Hospitals-Case Medical Center, Cleveland, Ohio, United States, 6 Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio, United States

Chronic kidney disease (CKD) is an important complication in sickle cell disease and begins in childhood. Unfortunately, current clinical measures of kidney function are insensitive to early kidney changes, a time point when therapies could be more effective. In this initial study, we used Arterial Spin Labeling and Diffusion Tensor Imaging techniques to assess kidney changes in pediatric SCD patients in comparison to healthy control subjects. Cortical Apparent Diffusion Coefficients (ADC), medullary Fractional Anisotropy (FA), and cortical perfusion were all significantly reduced in young SCD patients. These quantitative MRI techniques could potentially compliment current clinical assessments of kidney function.

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