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Abstract #2160

Volumetric T1 Mapping of liver parenchyma at 3 T: Diagnosing Liver Cirrhosis

Niklas Verloh 1 , Claudia Fellner 1 , Michael Haimerl 1 , Mona Schlabeck 1 , Miriam Rabea Kukach 2 , Marcel D. Nickel 2 , Christian Stroszczynski 1 , and Philipp Wiggermann 1

1 Department of Radiology, University Hospital Regensburg, Regensburg, Germany, 2 MR Applications Development, Siemens AG, Healthcare Sector, Erlangen, Germany

The purpose of the study was to assess the ability of volumetric T1 mapping of Gd-EOB-DTPA-enhanced MRI to detect liver cirrhosis. Mean T1 relaxation time of the whole liver parenchyma was used to calculate the reduction rate between plain and enhanced T1 relaxation time. Patients with and without liver cirrhosis were analyzed regarding their reduction rate. The reduction rate of the whole liver was significantly (p ≤ 0.001) lower in patients with liver cirrhosis (35% 8%) compared to patients with normal liver function (58% 6%). The evaluation of changes in T1 mapping of liver parenchyma in Gd-EOB-DTPA-enhanced images may serve as a useful new, non-invasive technique to quantify liver cirrhosis

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