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Abstract #2159

A study on T1 mapping of Healthy and Fibrotic Human Liver

Anup Singh 1 , Damodar Reddy 1 , Mohammad Haris 1,2 , Kejia Cai 1,3 , Rebecca Wells 4 , Emma E. Furth 5 , K. Rajender Reddy 4 , Hari Hariharan 1 , and Ravinder Reddy 1

1 Radiology, University of Pennsylvania, Philadelphia, PA, United States, 2 Research Branch, Sidra Medical and Research Center, Doha, Qatar, 3 Radiology, University of Illinois at Chicago, Chicago, IL, United States, 4 Department of Medicine, University of Pennsylvania, Philadelpha, PA, United States, 5 Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelpha, PA, United States

Objective of current study was to evaluate T1 changes in fibrotic human liver. In the current study, T1 mapping and analysis of healthy (n=10) and fibrotic (n=10) livers of human subjects on 1.5T clinical scanner were carried out. T1 values were significantly higher in fibrotic livers compared to healthy livers. In addition, T1 maps of some of the fibrotic liver were more heterogeneous compared to healthy liver. Histogram analysis of T1 values was also performed. Results from this preliminary study show the potential of staging liver fibrosis based upon increased T1 values in combination with width of histogram and mode values.

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