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Abstract #2134

Standard compared to optimized mDIXON liver fat fraction imaging

Jurgen H. Runge 1 , Bram F. Coolen 1 , Edmond Balidemaj 2 , Ulrich H. Beuers 3 , Aart J. Nederveen 1 , and Jaap Stoker 1

1 Radiology, Academic Medical Center, Amsterdam, Netherlands, 2 Radiotherapy, Academic Medical Center, Amsterdam, Netherlands, 3 Gastroenterology & Hepatology, Academic Medical Center, Amsterdam, Netherlands

Standard mDIXON fat-water imaging can be used to reconstruct quantitative fat fraction maps. However, a non-zero intercept of circa 4% is reported upon in recent literature. We optimized the mDIXON protocol by increasing the TR to reduce T1-weighting and by choosing more echoes with asymmetric TEs for a higher NSA. We investigated in phantoms and patients whether this optimized protocol increased accuracy in comparison to 1 H-MRS. In phantoms, the non-zero intercept was resolved, but not in patients. Differences in T1 values of phantoms and tissue may explain why the issue remained for in vivo measurements.

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