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Abstract #2133

Accuracy of liver fat quantification by CT, MRI and US: a prospective comparison with Magnetic Resonance Spectroscopy (MRS)

Harald Kramer 1,2 , Mark A Kliewer 2 , Perry J Pickhardt 2 , Diego Hernando 2 , Gunag-Hong Chen 2 , and Scott B Reeder 2,3

1 Department of Radiology, Ludwig-Maximilians-University Munich, Munich, Germany, 2 Department of Radiology, University of Wisconsin - Madison, Madison, Wisconsin, United States, 3 Department of Medical Physics, University of Wisconsin - Madison, Madison, Wisconsin, United States

Accumulation of triglycerides in hepatocytes is the hallmark feature of non-alcoholic fatty liver disease and can lead to inflammation, fibrosis and cirrhosis. Since the accepted diagnostic standard (biopsy) is invasive and suffers from poor sampling variability, there is a need for a comprehensive, accurate and non-invasive quantitative biomarker. We evaluated a proton density fat-fraction chemical-shift based MRI technique, dual-energy CT and US shear-wave velocity in comparison to MR spectroscopy. PDFF-MRI shows excellent correlation with MRS whereas CT Hounsfield-Units and CT fat decomposition showed good and moderate correlation, respectively. US SW did not demonstrate any correlation with MRS.

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