Abstract #2133
Accuracy of liver fat quantification by CT, MRI and US: a prospective comparison with Magnetic Resonance Spectroscopy (MRS)
Harald Kramer 1,2 , Mark A Kliewer 2 , Perry J Pickhardt 2 , Diego Hernando 2 , Gunag-Hong Chen 2 , and Scott B Reeder 2,3
1
Department of Radiology, Ludwig-Maximilians-University
Munich, Munich, Germany,
2
Department
of Radiology, University of Wisconsin - Madison,
Madison, Wisconsin, United States,
3
Department
of Medical Physics, University of Wisconsin - Madison,
Madison, Wisconsin, United States
Accumulation of triglycerides in hepatocytes is the
hallmark feature of non-alcoholic fatty liver disease
and can lead to inflammation, fibrosis and cirrhosis.
Since the accepted diagnostic standard (biopsy) is
invasive and suffers from poor sampling variability,
there is a need for a comprehensive, accurate and
non-invasive quantitative biomarker. We evaluated a
proton density fat-fraction chemical-shift based MRI
technique, dual-energy CT and US shear-wave velocity in
comparison to MR spectroscopy. PDFF-MRI shows excellent
correlation with MRS whereas CT Hounsfield-Units and CT
fat decomposition showed good and moderate correlation,
respectively. US SW did not demonstrate any correlation
with MRS.
This abstract and the presentation materials are available to members only;
a login is required.
Join Here
