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Abstract #2088

Multiexponential T 2 and Quantitative Magnetization Transfer in Rodent Brain Models of Hypomyelination

Kathryn L West 1 , Nathaniel D Kelm 1 , Daniel F Gochberg 2 , Robert P Carson 3 , Kevin C Ess 3 , and Mark D Does 1,4

1 Biomedical Engineering, Vanderbilt University, Nashville, TN, United States, 2 Radiology and Radiological Sciences, Vanderbilt University, TN, United States, 3 Neurology, Vanderbilt University, TN, United States, 4 Vanderbilt.University Institute of Imaging Science, Vanderbilt University, TN, United States

Myelin water imaging (MWI) by multi-exponential transverse relaxation (MET 2 ) and quantitative Magnetization Transfer (qMT) provide valuable information about myelin content and microstructure in white matter, yet have a known discord between measures. 3D high resolution imaging protocols allow for efficient whole brain evaluation of abnormal myelination in recently developed hypomyelinated mouse models. In addition, comparing MWF and PSR measures to histology can provide insight to better understand white matter microstructure.

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