Meeting Banner
Abstract #2087

Histological correlation of manganese enhanced MRI in the demyelinating disease model brain.

Masaki Fukunaga 1,2 , Makoto Masumura 3 , Shuichi Koda 3 , Tomokazu Shimonaga 3 , Ryuichi Nakamura 3 , Yuki Mori 1 , and Yoshichika Yoshioka 1,2

1 Biofunctional Imaging, IFReC, Osaka University, Suita, Osaka, Japan, 2 Brain Functional Imaging Technologies, CiNet, NICT-Osaka University, Suita, Osaka, Japan, 3 Asubio Pharma Co. Ltd., Kobe, Hyogo, Japan

Cuprizone is a mitochondrial toxin that induces apoptosis of oligodendrocytes and demyelination in the central nervous system, and is used for animal model of de- and re-myelination in multiple sclerosis. Recently, manganese enhanced MRI (MEMRI) is utilized to reveal the mechanisms of neuroinflammatory and neurodegenerative disorders, especially it enhances image contrast of the glial (astrocytes and microglia) activations in the pathological conditions. In this study, we investigated manganese contrast enhancement in cuprizone induced demyelinated mouse brain using 11.7T ultra high field MRI, and analyzed with histology and glial marker expressions.

This abstract and the presentation materials are available to members only; a login is required.

Join Here