Abstract #2062
Pathological substrate of MRI-derived cortical atrophy in multiple sclerosis
Veronica Popescu 1 , Roel Klaver 2 , Yvon Galis-de Graaf 2 , Pieter Voorn 2 , Dirk Knol 3 , Adriaan Versteeg 1 , Geert Schenk 2 , Frederik Barkhof 1 , Helga E De Vries 4 , Hugo Vrenken 1,5 , and Jeroen JG Geurts 2
1
Radiology and Nuclear Medicine, VU
University Medical Center, Amsterdam, Netherlands,
2
Anatomy
and Neurosciences, VU University Medical Center,
Amsterdam, Netherlands,
3
Epidemiology
and Biostatistics, VU University Medical Center,
Amsterdam, Netherlands,
4
Molecular
Cell Biology and Immunology, VU University Medical
Center, Amsterdam, Netherlands,
5
Physics
and Medical Technology, VU University Medical Center,
Amsterdam, Netherlands
In multiple sclerosis grey matter becomes atrophic.
Atrophy correlates with disability and cognitive
impairment. It is unknown which tissue component causes
this atrophy. In a combined post-mortem
MRI-histopathology study, five anatomical regions were
systematically sampled from 11 brain donors with MS.
After generalized estimating equations with false
discovery rate correction two predictors survived:
axonal density in the superior frontal gyrus and
astrocytes numbers in the inferior frontal gyrus.
Cortical atrophy seems predominantly driven by
neuropilema changes and gliosis, and not by inflammation
or demyelination. This points towards the need to
intensify the search for neuroprotective medication in
MS.
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