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Abstract #2061

Is primary progressive multiple sclerosis an independent disease entity? An ultrahigh field MRI lesion analysis

Joseph Kuchling 1 , Ivan Bozin 1 , Jan Drr 1 , Caspar Pfueller 1 , Lutz Harms 2 , Thoralf Niendorf 3 , Friedemann Paul 1 , Tim Sinnecker 1 , and Jens Wuerfel 4

1 NeuroCure Clinical Research Center, Berlin, Berlin, Germany, 2 Department of Neurology, Charit Universittsmedizin Berlin, Berlin, Berlin, Germany, 3 Berlin Ultrahigh Field Facility (B.U.F.F), Max Delbrueck Center for Molecular Medicine, Berlin, Berlin, Germany, 4 Institute of Neuroradiology, University Medicine Goettingen, Goettingen, Germany

Differences between primary progressive (PP) and relapsing remitting (RR) multiple sclerosis (MS) have been described, raising the question whether PPMS is part of the MS disease spectrum or a disease entity of its own. We addressed this issue by investigating RRMS and PPMS lesions using UHF-MRI with high spatial resolution resolution. However, gray and white matter lesions could not differentiate RRMS and PPMS regarding plaque morphology, distribution and appearance. Our findings support the hypothesis that PPMS is part of the MS disease spectrum and does not represent a disease entity of its own.

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