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Abstract #2031

MRI-based quantification of the CMRO 2 response to apnea in patients with obstructive sleep apnea

Zachary B Rodgers 1 , Varsha Jain 1 , Michael C Langham 1 , Sarah Leinwand 1 , Richard J Schwab 1 , and Felix W Wehrli 1

1 University of Pennsylvania, Philadelphia, PA, United States

It has been hypothesized that the repeated nocturnal apnea experienced by patients with obstructive sleep apnea (OSA) results in blunting of the normal neurovascular apneic response, causing repeated nocturnal hypoxia which manifests as neurologic comorbidities. In this study, a recently developed method for rapid MRI-based quantification of CMRO 2 was used to determine whether OSA results in reductions in resting-state CMRO 2 and the CMRO 2 response to apnea. Preliminary results, though not statistically significant, suggest OSA-associated reductions in both baseline and apneic CMRO 2 .

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