Abstract #2031
MRI-based quantification of the CMRO 2 response to apnea in patients with obstructive sleep apnea
Zachary B Rodgers 1 , Varsha Jain 1 , Michael C Langham 1 , Sarah Leinwand 1 , Richard J Schwab 1 , and Felix W Wehrli 1
1
University of Pennsylvania, Philadelphia,
PA, United States
It has been hypothesized that the repeated nocturnal
apnea experienced by patients with obstructive sleep
apnea (OSA) results in blunting of the normal
neurovascular apneic response, causing repeated
nocturnal hypoxia which manifests as neurologic
comorbidities. In this study, a recently developed
method for rapid MRI-based quantification of
CMRO
2
was
used to determine whether OSA results in reductions in
resting-state
CMRO
2
and
the
CMRO
2
response
to apnea. Preliminary results, though not statistically
significant, suggest OSA-associated reductions in both
baseline and apneic
CMRO
2
.
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