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Abstract #1985

White matter abnormalities in mesocorticolimbic network of drug nave ADHD children by diffusion tensor imaging

Lizhou Chen 1 , Xinyu Hu 1 , Qi Liu 1 , Yi Liao 1 , Ning He 2 , Fei Li 1 , Ying Chen 2 , Lanting Guo 2 , Qiyong Gong 1 , and Xiaoqi Huang 1

1 Huaxi MR Research Center(HMRRC), West China Hospital of Sichuan University, Chengdu, Sichuan, China, 2 Department of Psychiatry, West China Hospital of Sichuan University, Chengdu, Sichuan, China

White matter (WM) abnormality had been studied with diffusion tensor imaging with inconsistent results while underline mechanism remained unclear. Present study performed in-depth investigation into WM abnormalities in a relatively large sample of ADHD children by using multiple diffusion parameters, including fractional anisotropy (FA), radial diffusivity and axial diffusivity. The relationship between FA and neuropsychiatric measurements was also explored. Increased FA with discrepant cellular alternating patterns was detected in left cingulate bundle and posterior-body of corpus callosum, and the alternation of FA correlated with some cognitive domains.

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