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Abstract #1984

Verbal Memory Function, Glutamate, and Cerebral Blood Flow in Older Adults with Schizophrenia

S. Andrea Wijtenburg 1 , Benjamin W Krause 1 , Frank Gaston 1 , Stephanie Korenic 1 , Sarah Nisonger 1 , Peter Kochunov 1 , Danny JJ Wang 2 , L Elliot Hong 1 , and Laura M Rowland 1,3

1 MPRC, University of Maryland School of Medicine, Baltimore, MD, United States, 2 Neurology, University of California Los Angeles, CA, United States, 3 Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, United States

Older adults with schizophrenia (SZ) have significant memory impairments when compared to healthy age-matched controls, and the pathophysiology of these memory impairments is poorly understood. Assessments of declarative verbal memory, glutamate, and regional cerebral blood flow from brain regions associated with verbal memory function (hippocampus and anterior cingulate) were conducted in older adults. Data were acquired on a 3T scanner from stable, chronic younger and older adults with SZ and age-matched controls. Results showed lower glutamate, CBF, and verbal memory scores in older adults with SZ.

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