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Abstract #1975

Preliminary Evidence of Pronounced Thinning in the Cortex of Attention Deficit Hyperactivity Disorder Boys with a comorbid Reading Disability

Dhruman D Goradia 1 , Charles Frank 1 , Andrew Lorence 1 , Brianne Mohl 1 , Dalal Khatib 1 , Usha Rajan 1 , Arthur Robin 1 , David R Rosenberg 1 , and Jeffrey A Stanley 1

1 Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, Michigan, United States

The prevalence of attention-deficit/hyperactivity disorder (ADHD) with a comorbid reading disability (RD) has been estimated to be as high as 45%. ADHD children with RD tend to have greater severity in cognition; however, morphological measures differentiating ADHD with RD from ADHD without RD remains poorly understood. The aim of this study is to investigate differences between subgroups in cortical thickness of key implicated areas in ADHD. As expected, ADHD with RD show a greater extent of cortex thinning than ADHD without RD in the prefrontal, parietal and cingulate areas, when compared to healthy individuals.

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