Abstract #1974
Volumetric morphometry and multivariate pattern analysis of white matter architecture in obsessive-compulsive disorder
Xinyu Hu 1 , Shiguang Li 1 , Lizhou Chen 1 , Qi Liu 1 , Yi Liao 1 , Fei Li 1 , Wanjie Tang 2 , Bin Li 2 , Yanchun Yang 2 , Qiyong Gong 1 , and Xiaoqi Huang 1
1
Huaxi MR Research Center(HMRRC), Department
of Radiology, West China Hospital of Sichuan University,
Chengdu, Sichuan Province, China,
2
Department
of Psychiatry, West China Hospital of Sichuan
University, Chengdu, Sichuan Province, China
White matter (WM) is suggested to play an important role
in pathology of obsessive-compulsive disorder (OCD). In
this study, we investigated the anatomic brain
structures alterations of WM in OCD patients using both
volumetric morphometry and multivariate pattern
analysis. Decreased WM volume was revealed in bilateral
external capsule of OCD patients compared to healthy
controls, while discriminative regions were mainly
involving the left middle frontal WM and bilateral
temporo-patieto-occipital junction. Current study
supported the potential translational role of WM for
individual level diagnosis in OCD.
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