Abstract #1957
Synaptic Amyloid Beta Affects Neural Conductivity But May Not Lead to Pre-synaptic Axonal Degeneration
Shu-Wei Sun 1 , Chen-Fang Chung 2 , Christopher Nishioka 3 , Hsiao-Fang Liang 2 , and Wei-Xing Shi 2
1
Loma Linda University, Loma Linda, CA,
United States,
2
Loma
Linda University, CA, United States,
3
University
of California, Riverside, CA, United States
Synaptic deficits and brain atrophy are two major
hallmarks in Alzheimers disease. Synaptic deficits
usually occur early in contrast to the neuronal loss
which usually occurs late. Thus, it is speculated that
the early synaptic deficits may facilitate the later
neuronal loss. A-beta was injected in the lateral
geniculate nucleus, which affected the synapses but not
the soma of RGCs. A-beta injected in axonal terminals
may impair synapses to adversely affect the neural
signal conduction. However, the injured synapses may not
lead to a retrograded axonal degeneration to cause a
neuronal loss.
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