Abstract #1951
Opposite neural trajectories of Apolipoprotein E 4 and 2 alleles with aging associate with different risks of Alzheimer s disease
Hao Shu 1,2 , Yongmei Shi 1 , Gang Chen 2 , Zan Wang 1 , Duan Liu 1 , Chunxian Yue 1 , B. Douglas Ward 2 , Wenjun Li 2 , Zhan Xu 2 , Guangyu Chen 2 , Qihao Guo 3 , Jun Xu 4 , Shi-Jiang Li 2 , and Zhijun Zhang 1
1
Neurologic Department of Affiliated ZhongDa
Hospital, Neuropsychiatric Institute and Medical School
of Southeast University, Nanjing, Jiangsu, China,
2
Department
of Biophysics, Medical College of Wisconsin, Milwaukee,
Wisconsin, United States,
3
Department
of Neurology, Huashan Hospital, Fudan University,
Shanghai, China,
4
Department
of Neurology, Affiliated Nanjing Brain Hospital,
Nanjing Medical University, Nanjing, Jiangsu, China
APOE ε4 allele is the genetic risk factor and ε2
allele is the protective factor of Alzheimer’s disease
(AD). However, the similar influences of the two alleles
on the brain function have challenged the conceptual
framework that the altered brain functions are directly
linked to AD development. Given aging is another risk
factor of AD, we utilized the resting-state functional
connectivity approach to demonstrate that the opposite
aging trajectories may contribute to the different AD
risks between the two alleles, indicating the
antagonistic pleiotropic property of APOE polymorphism
and the necessity for including aging in AD related
imaging genetics study.
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