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Abstract #1951

Opposite neural trajectories of Apolipoprotein E 4 and 2 alleles with aging associate with different risks of Alzheimer s disease

Hao Shu 1,2 , Yongmei Shi 1 , Gang Chen 2 , Zan Wang 1 , Duan Liu 1 , Chunxian Yue 1 , B. Douglas Ward 2 , Wenjun Li 2 , Zhan Xu 2 , Guangyu Chen 2 , Qihao Guo 3 , Jun Xu 4 , Shi-Jiang Li 2 , and Zhijun Zhang 1

1 Neurologic Department of Affiliated ZhongDa Hospital, Neuropsychiatric Institute and Medical School of Southeast University, Nanjing, Jiangsu, China, 2 Department of Biophysics, Medical College of Wisconsin, Milwaukee, Wisconsin, United States, 3 Department of Neurology, Huashan Hospital, Fudan University, Shanghai, China, 4 Department of Neurology, Affiliated Nanjing Brain Hospital, Nanjing Medical University, Nanjing, Jiangsu, China

APOE ε4 allele is the genetic risk factor and ε2 allele is the protective factor of Alzheimer’s disease (AD). However, the similar influences of the two alleles on the brain function have challenged the conceptual framework that the altered brain functions are directly linked to AD development. Given aging is another risk factor of AD, we utilized the resting-state functional connectivity approach to demonstrate that the opposite aging trajectories may contribute to the different AD risks between the two alleles, indicating the antagonistic pleiotropic property of APOE polymorphism and the necessity for including aging in AD related imaging genetics study.

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