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Abstract #1945

White Matter Hyperintensities and Physical Activity in People at Risk of Alzheimer's Disease

Bernd Merkel 1,2 , Nicola T. Lautenschlager 3 , Kay Cox 4 , David Ames 2,5 , Kathryn A. Ellis 3 , Elizabeth Cyarto 5 , Pramit Phal 1 , Bob Tran 2 , Christopher Steward 1,2 , and Patricia M. Desmond 1,2

1 Radiology, Royal Melbourne Hospital, Parkville, VIC, Australia, 2 The University of Melbourne, VIC, Australia, 3 Psychiatry, The University of Melbourne, VIC, Australia, 4 University of Western Australia, Perth, Western Australia, Australia, 5 National Ageing Research Institute, Parkville, VIC, Australia

White matter hyperintensities (WMH), which appear bright on T2-FLAIR images, are considered to reflect pathology of brain vessels and have been linked to age-related cognitive changes as well as cognitive impairments and complaints. Physical activity (PA) may be a modifiable and potentially protective factor for Alzheimers Disease (AD). However, its effect on cerebrovascular disease and AD is still not clear. We segmented and quantified WMH and hippocampal volumes of patients with subjective memory complaints (SMC) and mild cognitive impairments (MCI), who are at increased risk of developing AD. The volumes were associated with different exercise-related assessments of PA.

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