Abstract #1944
The spectrum of cortical microinfarcts; a post-mortem classification study with 7Tesla MRI
Susanne J. van Veluw 1 , Jaco J.M. Zwanenburg 2 , Wim G.M. Spliet 3 , Peter R. Luijten 2 , and Geert Jan Biessels 1
1
Neurology, Brain Center Rudolf Magnus,
University Medical Center Utrecht, Utrecht, Netherlands,
2
Radiology,
University Medical Center Utrecht, Utrecht, Netherlands,
3
Pathology,
University Medical Center Utrecht, Utrecht, Netherlands
Cerebral microinfarcts are common neuropathological
findings in the aging human brain, and correlate
strongly with cognitive decline. Post-mortem brain MRI
at high field strength (7Tesla) has proven to be useful
in identifying microinfarcts and to translate findings
to in vivo. In the current study, we have used
post-mortem 7Tesla MRI to characterise microinfarct
subtypes. By using a targeted approach, 4 types of
intracortical microinfarcts could be identified. Future
studies can now look into the causes of these abundant
manifestations of small vessel disease to better
understand their role in aging and dementia.
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