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Abstract #1944

The spectrum of cortical microinfarcts; a post-mortem classification study with 7Tesla MRI

Susanne J. van Veluw 1 , Jaco J.M. Zwanenburg 2 , Wim G.M. Spliet 3 , Peter R. Luijten 2 , and Geert Jan Biessels 1

1 Neurology, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, Netherlands, 2 Radiology, University Medical Center Utrecht, Utrecht, Netherlands, 3 Pathology, University Medical Center Utrecht, Utrecht, Netherlands

Cerebral microinfarcts are common neuropathological findings in the aging human brain, and correlate strongly with cognitive decline. Post-mortem brain MRI at high field strength (7Tesla) has proven to be useful in identifying microinfarcts and to translate findings to in vivo. In the current study, we have used post-mortem 7Tesla MRI to characterise microinfarct subtypes. By using a targeted approach, 4 types of intracortical microinfarcts could be identified. Future studies can now look into the causes of these abundant manifestations of small vessel disease to better understand their role in aging and dementia.

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