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Abstract #1937

Differentiating Microbleeds from Plaque in Alzheimers Disease

Michael Horn 1 , Nyoman Kurniawan 2 , Marianne D Keller 2 , Ian M Brereton 2 , and Graham J Galloway 2

1 University of Melbourne, Melbourne, Victoria, Australia, 2 Centre for Advanced Imaging, University of Queensland, Brisbane, Queensland, Australia

Automated detection of amyloid plaques and microbleeds visualised using MRI phase image and susceptibility weighted imaging (SWI) acquired using an ultra-high field magnet will be demonstrated. We hypothesised that the phase shifts between amyloid plaques and microbleeds are significantly distinct, and therefore fine-tuning the weighting of the phase map for creating SWI could help distinguishing microbleeds from plaques. The validity of this methodology will be assessed using a fixed brain from an APP23 mouse model of Alzheimers Dementia.

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