Abstract #1937
Differentiating Microbleeds from Plaque in Alzheimers Disease
Michael Horn 1 , Nyoman Kurniawan 2 , Marianne D Keller 2 , Ian M Brereton 2 , and Graham J Galloway 2
1
University of Melbourne, Melbourne,
Victoria, Australia,
2
Centre
for Advanced Imaging, University of Queensland,
Brisbane, Queensland, Australia
Automated detection of amyloid plaques and microbleeds
visualised using MRI phase image and susceptibility
weighted imaging (SWI) acquired using an ultra-high
field magnet will be demonstrated. We hypothesised that
the phase shifts between amyloid plaques and microbleeds
are significantly distinct, and therefore fine-tuning
the weighting of the phase map for creating SWI could
help distinguishing microbleeds from plaques. The
validity of this methodology will be assessed using a
fixed brain from an APP23 mouse model of Alzheimers
Dementia.
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