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Abstract #1936

Amyloid plaques detection by MRI: comparison of five mouse models of amyloidosis

Matthias Vandesquille 1,2 , Chrystelle Po 1,2 , Mathieu Santin 1,3 , Emmanuel Comoy 4 , and Marc Dhenain 1

1 MIRCen, CEA, Fontenay-aux-Roses, France, 2 Institut Pasteur, Paris, France, 3 ICM, Hpital de la Piti Salptrire, Paris, France, 4 SEPIA, CEA, Fontenay-aux-Roses, France

Amyloid plaques are one of the hallmarks of Alzheimers disease and numerous mouse models of amyloidosis have been developed to study the pathology. In APP sl /PS1 M146L mice amyloid plaques can be detected by in vivo MRI thanks to gadolinium-staining procedure, a method based on the intravenous or intracerebroventricular administration of gadolinium contrast agent to the mice. The present work evaluated gadolinium-staining procedure to compare the in vivo and ex vivo MRI detection of amyloid plaques in five different mouse strains developing amyloidosis. Depending on the strain, the number, the size and the contrast of the plaques are highly different.

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