Abstract #1931
Altered Resting-State Connectivity of Hippocampus with Default Mode Network In Type 2 Diabetes
Hui Zhang 1 , Ying Hao 1 , Brad Manor 1,2 , Jue Zhang 1,3 , Jing Fang 1,3 , and Vera Novak 4
1
Academy for Advanced Interdisciplinary
Studies, Peking University, Beijing, Beijing, China,
2
Division
of Gerontology, Beth Israel Deaconess Medical Center
(BIDMC), Harvard Medical School, Boston, Massachusetts,
United States,
3
College
of Enigneering, Peking University, Beijing, Beijing,
China,
4
Department
of Neurology, Beth Israel Deaconess Medical Center
(BIDMC), Harvard Medical School, Boston, Massachusetts,
United States
Type 2 Diabetes mellitus (T2DM) is a major risk factor
for cognitive impairment, vascular dementia and
Alzheimers disease (AD). It accelerates brain aging,
leads to insulin resistance, and insulin transport.
Intranasal insulin (INI) administration improved
cognition and memory in healthy young and older people,
but also in patients with cognitive impairment or mild
AD. The mechanism for INI-related improvement of memory
(hippocampus function) remains unclear. In our research,
resting state fMRI was used to study connectivity
between hippocampus and default mode network (DMN) after
the administration of intranasal insulin or placebo in
type 2 DM and controls adults.
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