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Abstract #1930

Different patterns of White matter and Grey matter involvement account for Behavioural and Psychological symptoms in Alzheimers disease

Elena Makovac 1 , Laura Serra 1 , Barbara Span 1 , Giovanni Giulietti 1 , Mario Torso 1 , Mara Cercignani 1,2 , Carlo Caltagirone 3,4 , and Marco Bozzali 5

1 Neuroimaging Laboratory, IRCCS Santa Lucia Foundation, Rome, Italy, 2 Clinical Imaging Sciences Centre, Brighton and Sussex Medical School, United Kingdom, 3 Deptment of Clinical and Behavioural Neurology, IRCCS Santa Lucia Foundation, Rome, Italy, 4 University of Rome Tor Vergata, Rome, Italy, 5 Neuroimaging Laboratory, IRCCS Santa Lucia Foundation, Italy

Behavioral disorders and psychological symptoms (BPSD) in Alzheimers Disease (AD) are known to correlate both with grey matter (GM) atrophy and white matter (WM) damage. Using probabilistic tractography and voxel based morphometry of the GM we were able to delineate precise patterns of correlation between WM damage in the Genu of the Corpus Callosum and GM atrophy in AD patients exhibiting four different BPSD clusters: mood alterations, frontal deficits, psychosis and apathy. Our data shows that BPSD are likely to be caused by a disconnection syndrome, rather than being a reactive response to accumulation of cognitive disabilities.

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