Abstract #1930
Different patterns of White matter and Grey matter involvement account for Behavioural and Psychological symptoms in Alzheimers disease
Elena Makovac 1 , Laura Serra 1 , Barbara Span 1 , Giovanni Giulietti 1 , Mario Torso 1 , Mara Cercignani 1,2 , Carlo Caltagirone 3,4 , and Marco Bozzali 5
1
Neuroimaging Laboratory, IRCCS Santa Lucia
Foundation, Rome, Italy,
2
Clinical
Imaging Sciences Centre, Brighton and Sussex Medical
School, United Kingdom,
3
Deptment
of Clinical and Behavioural Neurology, IRCCS Santa Lucia
Foundation, Rome, Italy,
4
University
of Rome Tor Vergata, Rome, Italy,
5
Neuroimaging
Laboratory, IRCCS Santa Lucia Foundation, Italy
Behavioral disorders and psychological symptoms (BPSD)
in Alzheimers Disease (AD) are known to correlate both
with grey matter (GM) atrophy and white matter (WM)
damage. Using probabilistic tractography and voxel based
morphometry of the GM we were able to delineate precise
patterns of correlation between WM damage in the Genu of
the Corpus Callosum and GM atrophy in AD patients
exhibiting four different BPSD clusters: mood
alterations, frontal deficits, psychosis and apathy. Our
data shows that BPSD are likely to be caused by a
disconnection syndrome, rather than being a reactive
response to accumulation of cognitive disabilities.
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