Meeting Banner
Abstract #1924

Voxel-based morphometery to detect the effect of APOE on brain grey matter changes in Parkinsons Disease

David Neil Manners 1 , Emil Malucelli 2 , Giuseppe Nicoletti 3 , Claudia Testa 1 , Caterina Tonon 1 , Aldo Quattrone 3 , and Raffaele Lodi 1

1 Dept of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Emilia Romagna, Italy, 2 Dept of Pharmacy and Biotechnology, University of Bologna, Bologna, Emilia Romagna, Italy, 3 National Research Council Neuroimaging Research Unit, University Magna Graecia, Catanzaro, Calabria, Italy

A voxel-based morphometry analysis was conducted on isotropic T1-weighted brain image volumes, acquired at 1.5 T, to determine whether variations in the APOE allele, known as a risk factor in disorders such as Alzheimers disease, are also associated with grey matter degenerative changes in patients with Parkinsons disease (PD), with or without dementia. Despite a small increase in whole brain CSF in patients with the ε4 allele, after accounting for age, brain size and dementia, no localized grey matter changes were detected. Variations in the APOE allele are not associated with grey matter degenerative changes in the PD patients studied.

This abstract and the presentation materials are available to members only; a login is required.

Join Here