Abstract #1923
Automated Tract Based Analysis of Diffusion Properties in Amyotrophic Lateral Sclerosis
Florian Franz Erich Borsodi 1 , Christian Langkammer 1 , Valeriu Culea 1 , Lukas Pirpamer 1 , Christian Enzinger 1,2 , Reinhold Schmidt 1 , Franz Fazekas 1 , and Stefan Ropele 1
1
Department of Neurology, Medical University
of Graz, Graz, Austria,
2
Division
of Neuroradiology, Medical University of Graz, Graz,
Austria
Previous approaches to study microstructural tissue
changes in the corticospinal tract (CST) of patients
suffering from amyotrophic lateral sclerosis (ALS) were
based on spatial statistics on a group level with its
inherent limitations. In our research, we applied a new
global probabilistic fiber tracking approach with an
automated seed region positioning to study diffusion
properties (FA, MD, RD, AD) in major white-matter tracts
of 23 ALS patients and 18 age-matched healthy controls.
In line with previous studies, we found significant
changes in the CST, while other tracts remained
unaffected.
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