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Abstract #1923

Automated Tract Based Analysis of Diffusion Properties in Amyotrophic Lateral Sclerosis

Florian Franz Erich Borsodi 1 , Christian Langkammer 1 , Valeriu Culea 1 , Lukas Pirpamer 1 , Christian Enzinger 1,2 , Reinhold Schmidt 1 , Franz Fazekas 1 , and Stefan Ropele 1

1 Department of Neurology, Medical University of Graz, Graz, Austria, 2 Division of Neuroradiology, Medical University of Graz, Graz, Austria

Previous approaches to study microstructural tissue changes in the corticospinal tract (CST) of patients suffering from amyotrophic lateral sclerosis (ALS) were based on spatial statistics on a group level with its inherent limitations. In our research, we applied a new global probabilistic fiber tracking approach with an automated seed region positioning to study diffusion properties (FA, MD, RD, AD) in major white-matter tracts of 23 ALS patients and 18 age-matched healthy controls. In line with previous studies, we found significant changes in the CST, while other tracts remained unaffected.

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